Cavum de línea media y disfunción del sistema límbico en individuos de 20 años o más que viven en zonas rurales del litoral ecuatoriano. Estudio de caso-control anidado en una cohorte poblacional.
Portada volumen 28 num 3

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Palabras clave

cavum vergae
cavum septum pellucidum
depresión clínica
módulo de depresión del cuestionario de salud del paciente

Cómo citar

H. Del Brutto, O., Estrella, D., M. Mera, R., Kiernan, J., & J. Sedler, M. (2021). Cavum de línea media y disfunción del sistema límbico en individuos de 20 años o más que viven en zonas rurales del litoral ecuatoriano. Estudio de caso-control anidado en una cohorte poblacional. Revista Ecuatoriana De Neurología, 28(3). Recuperado a partir de https://revecuatneurol.temp.publicknowledgeproject.org/index.php/revecuatneurol/article/view/1693

Resumen

Background: Persistence of cavum septum pellucidum (CSP) and cavum vergae (CV) into adulthood and their association with mood disorders is unknown. 

Objective: We aimed to assess persistence of these cava in Atahualpa cohort individuals, and their association with clinical depression (as a surrogate of limbic system dysfunction). 

Methods: Cases were defined as Atahualpa residents aged ≥20 years with CSP and/or CV and paired 1:1 to age- and sex-matched randomly-selected controls. A board-certified psychiatrist (blinded to case-control status) interviewed individuals with the aid of the Patient Health Questionnaire depression module (PHQ-9) to establish a diagnosis of clinical depression. The McNemar’s test and conditional logistic regression models were fitted to assess the independent association between persistence of CSP and/or CV and clinical depression (as the dependent variable). 

Results: Of 1,298 individuals undergoing a head CT, 51 (3.9%) had a CSP and/or CV. The selection process for the nested case-control study on the Atahualpa cohort (after excluding eight missing individuals with midline cava) generated 43 pairs. Nine of 43 case-patients (20.9%) and only two control subjects (4.7%) had moderate-to-severe scores on the PHQ-9 (cutoff ≥10 points). Clinical depression was significantly more frequent among case-patients than controls by the McNemar’s test (OR: 8; 95% C.I.: 1.1 – 354.9) and the conditional logistic regression model (OR: 8; 95% C.I.: 1.00 – 63.96). 

Conclusions: This study provides epidemiological evidence favoring the association between midline cava and clinical depression, supporting their relationship with limbic system dysfunction.