Historical perspective and current scenarios of the antiganglioside syndrome

Abstract

The antiganglioside syndromes constitute a large clinical spectrum. Its knwolegde has evolved from the classical pure clinical descriptions to a wide development of the immunopathology underlying these processes and its possibilities of treatment. In this work we realize a bibliographical review analyzing its evolution from a historical perspective to date at four levels: cli- nical, topographic, immunologic, and therapeutic. We analyze critically well-known topographical and immunologic notions that are scarcely integrated in daily clinical practice. We debate about the need of establish a new nomenclature for these syndromes in two levels: clinical and immunologic. Finally, we review the current and under development therapeutic lines.